Tumor Targeted Therapies: Strategies for Killing Cancer but not Normal Cells
Affiliation: 220 Handan Road, Fudan University Genetic Bldg. Room 3005, Shanghai 200433, P. R. China.
Tumors are complex tissues composed of different cell types that interact with one another by building up
complicated intra-and intercellular signal networks. In addition to the proliferating cancer cells, tumors also contain normal
cells which are recruited and eroded by cancer cells to form tumor-supportive stroma and these natively normal stromal
cells actively participate in the tumor development and progression by editing some of the behaviors of cancer cells
and creating a tumor microenvironment to foster the rapid growth and proliferation of cancer cells. Therefore, the genetically
mutated cancer cells are the cell of origin and driving forces for tumor development and progression. Selectively targeting
cancer cells to induce tumor cell death and intercepting or normalizing the interaction signal network between the
cancer and stromal cells are the bases for current cancer therapies. Identification of the mutated components in the intrinsic
and extrinsic apoptotic pathways in cancer cells and designing small molecule mimetics or agonists to eradicate cancer
cells by selectively targeting these mutations represent the attractive strategies for modern cancer therapy.
Keywords: Apoptosis, chemotherapy, TRAIL, p53, BAX, cancer drug targets, drug resistance.
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