Current Cancer Therapy Reviews

Kurt S. Zaenker
Institute of Immunology and Experimental Oncology University Witten/Herdecke
Stockumerstraße 10, 58448 Witten
Germany

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Nanoparticulate Drug Delivery Systems for Treatment of Hepatocellular Carcinoma

Author(s): Shruti S. Shrikhande, Darshana S. Jain, Rajani B. Athawale and Amrita N. Bajaj

Affiliation: C.U.Shah College of Pharmacy, S.N.D.T Women's University, Santacruz (W), Mumbai-400 049, Maharashtra, India.

Keywords: Asialoglycoprotein receptors, dendrimers, hepatocellular carcinoma, inorganic nanoparticles, Liposomes, magnetic nanoparticles, polymeric nanoparticles, solid lipid nanoparticles.

Abstract:

Hepatocellular carcinoma is one of the most prevalent forms of cancer throughout the globe. Despite this, therapy of HCC continues to be challenging because of the drawbacks of current treatments options. Lately, nanoparticulate based drug delivery systems have been employed for treatment of variety of cancers, including primary hepatic cancer. These nanocarriers can be tailored to meet the desired requirements on the basis of their size, charge, composition and surface properties. Following attachment to a targeting ligand, the deleterious and toxic effects associated with the drug could be reduced to a minimum, along with site selective delivery of antineoplastic agents. This article attempts to present a review of various nanoparticulate delivery systems which have been explored for the remedy of hepatocellular carcinoma.

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Article Details

VOLUME: 10
ISSUE: 1
Page: [22 - 33]
Pages: 12
DOI: 10.2174/157339471001140815151936