Nanoparticulate Drug Delivery Systems for Treatment of Hepatocellular Carcinoma
Shruti S. Shrikhande, Darshana S. Jain, Rajani B. Athawale and Amrita N. Bajaj
Affiliation: C.U.Shah College of Pharmacy, S.N.D.T Women's University, Santacruz (W), Mumbai-400 049, Maharashtra, India.
Keywords: Asialoglycoprotein receptors, dendrimers, hepatocellular carcinoma, inorganic nanoparticles, Liposomes, magnetic
nanoparticles, polymeric nanoparticles, solid lipid nanoparticles.
Hepatocellular carcinoma is one of the most prevalent forms of cancer throughout the globe. Despite this, therapy
of HCC continues to be challenging because of the drawbacks of current treatments options. Lately, nanoparticulate
based drug delivery systems have been employed for treatment of variety of cancers, including primary hepatic cancer.
These nanocarriers can be tailored to meet the desired requirements on the basis of their size, charge, composition and surface
properties. Following attachment to a targeting ligand, the deleterious and toxic effects associated with the drug could
be reduced to a minimum, along with site selective delivery of antineoplastic agents. This article attempts to present a review
of various nanoparticulate delivery systems which have been explored for the remedy of hepatocellular carcinoma.
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