Design, Synthesis, and Antitumor Activity of Novel Acylate of 6-OH at 1- O-acetylbritannilactone

Shouxin      Liu; Jun      Feng; He      Liu; Junzhang      Li; Xia      Tian

Abstract

N-(α-Alkyloxime-3-phenylpropionyl) proline was designed and synthesized as an acylating agent to modify the 6-OH of 1-O-acetylbritannilactone. Eight intermediates and eight target compounds were obtained. The structures of sixteen novel compounds were characterized by ¹HNMR, IR and HRMS. The activities against HL-60 and Bel-7402 cell lines were tested, the IC₅₀ values of compound IVg were 2.7 μM and 4.3 μM, respectively.

Keywords: Acylation compound, antitumor, britannilactone, synthesis.

« Previous Next »

Graphical Abstract

Rights & Permissions Print Cite

Medicinal Chemistry

Title:Design, Synthesis, and Antitumor Activity of Novel Acylate of 6-OH at 1- O-acetylbritannilactone

Volume: 11 Issue: 2

Author(s): Shouxin Liu, Jun Feng, He Liu, Junzhang Li and Xia Tian

Affiliation:

Keywords: Acylation compound, antitumor, britannilactone, synthesis.

Abstract: N-(α-Alkyloxime-3-phenylpropionyl) proline was designed and synthesized as an acylating agent to modify the 6-OH of 1-O-acetylbritannilactone. Eight intermediates and eight target compounds were obtained. The structures of sixteen novel compounds were characterized by ¹HNMR, IR and HRMS. The activities against HL-60 and Bel-7402 cell lines were tested, the IC₅₀ values of compound IVg were 2.7 μM and 4.3 μM, respectively.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Liu Shouxin, Feng Jun, Liu He, Li Junzhang and Tian Xia, Design, Synthesis, and Antitumor Activity of Novel Acylate of 6-OH at 1- O-acetylbritannilactone, Medicinal Chemistry 2015; 11 (2) . https://dx.doi.org/10.2174/1573406410666140815123216

DOI https://dx.doi.org/10.2174/1573406410666140815123216	Print ISSN 1573-4064
Publisher Name Bentham Science Publisher	Online ISSN 1875-6638

About this journal

Call for Papers in Thematic Issues

Submission closes on : 08 May, 2024

Carbohydrates in Computational and Medicinal Chemistry

Carbohydrates are the most essential organic molecules and are involved in the maintenance of various physiological and metabolic processes in living organisms. Carbohydrate-based compounds have come to the attention of researchers because of their significant contributions to biological functions, such as cell development and cell proliferation, connections between several cells, ...read more

Guest Editor(s): S. M.A. Kawsar

Submission closes on : 11 May, 2024

Recent Advances in the Medicinal Chemistry of Cancer

Scope of the Thematic Issue: Correlation between structure and function is one of the important aspects of the success of anti-cancer compounds associated with their structure-activity interactions, physiology, biochemical, molecular, and genetic processes. Overcoming these obstacles is key to obtaining further insights into developments in rational drug design, bioorganic chemistry, ...read more

Guest Editor(s): I??l Y?ld?r?m