N-(α-Alkyloxime-3-phenylpropionyl) proline was designed and synthesized as an acylating agent to modify the
6-OH of 1-O-acetylbritannilactone. Eight intermediates and eight target compounds were obtained. The structures of sixteen
novel compounds were characterized by 1HNMR, IR and HRMS. The activities against HL-60 and Bel-7402 cell
lines were tested, the IC50 values of compound IVg were 2.7 μM and 4.3 μM, respectively.
Keywords: Acylation compound, antitumor, britannilactone, synthesis.
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