Medicinal Chemistry

Atta-ur-Rahman  
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: mc@benthamscience.org

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Design, Synthesis, and Antitumor Activity of Novel Acylate of 6-OH at 1- O-acetylbritannilactone

Author(s): Shouxin Liu, Jun Feng, He Liu, Junzhang Li, Xia Tian.

Graphical Abstract:


Abstract:

N-(α-Alkyloxime-3-phenylpropionyl) proline was designed and synthesized as an acylating agent to modify the 6-OH of 1-O-acetylbritannilactone. Eight intermediates and eight target compounds were obtained. The structures of sixteen novel compounds were characterized by 1HNMR, IR and HRMS. The activities against HL-60 and Bel-7402 cell lines were tested, the IC50 values of compound IVg were 2.7 μM and 4.3 μM, respectively.

Keywords: Acylation compound, antitumor, britannilactone, synthesis.

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Article Details

VOLUME: 11
ISSUE: 2
Page: [200 - 205]
Pages: 6
DOI: 10.2174/1573406410666140815123216
Price: $58