Abstract
Tuberculosis is essentially a curable disease but inspite of a WHO approved DOTS therapy, it still continues to ravage mankind. This situation is exacerbated by long course of chemotherapy, increasing drug resistance and co-emergence with HIV. The TB drug pipeline remained stagnant for a long time with no new drug approved till FDA approval for Bedaquiline. This situation has now improved with a number of agents in pre-clinical and clinical development against M. tuberculosis. In this review, we are focusing on some of the newer drugs in discovery and preclinical development against M. tuberculosis.
Keywords: Clinical strains, drugs, MIC, Mycobacterium, pre-clinical development, tuberculosis.
Current Respiratory Medicine Reviews
Title:Current Approaches for New TB Drugs
Volume: 10 Issue: 2
Author(s): Shilpika Pandey, Isha Soni, Neha Topno, Arunava Dasgupta and Sidharth Chopra
Affiliation:
Keywords: Clinical strains, drugs, MIC, Mycobacterium, pre-clinical development, tuberculosis.
Abstract: Tuberculosis is essentially a curable disease but inspite of a WHO approved DOTS therapy, it still continues to ravage mankind. This situation is exacerbated by long course of chemotherapy, increasing drug resistance and co-emergence with HIV. The TB drug pipeline remained stagnant for a long time with no new drug approved till FDA approval for Bedaquiline. This situation has now improved with a number of agents in pre-clinical and clinical development against M. tuberculosis. In this review, we are focusing on some of the newer drugs in discovery and preclinical development against M. tuberculosis.
Export Options
About this article
Cite this article as:
Pandey Shilpika, Soni Isha, Topno Neha, Dasgupta Arunava and Chopra Sidharth, Current Approaches for New TB Drugs, Current Respiratory Medicine Reviews 2014; 10 (2) . https://dx.doi.org/10.2174/1573398X10666140813201210
DOI https://dx.doi.org/10.2174/1573398X10666140813201210 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Drug-induced Inhibition and Trafficking Disruption of ion Channels: Pathogenesis of QT Abnormalities and Drug-induced Fatal Arrhythmias
Current Cardiology Reviews Human Tuberculosis. III. Current and Prospective Approaches in Anti-Tubercular Therapy
Current Medicinal Chemistry Structure of the Cytoplasmic Segment of Histidine Kinase Receptor QseC: A Key Player in Bacterial Virulence
Protein & Peptide Letters SVM Prediction of Ligand-binding Sites in Bacterial Lipoproteins Employing Shape and Physio-chemical Descriptors
Protein & Peptide Letters Insights into sRNA Genes Regulated by Two-Component Systems in the <i>Bacillus cereus</i> Group
Current Bioinformatics Hybrid Imidazole-Pyridine Derivatives: An Approach to Novel Anticancer DNA Intercalators
Current Medicinal Chemistry Editorial [Hot Topic: TB Drug Development (Guest Editor: Courtney C. Aldrich)]
Current Topics in Medicinal Chemistry Current Study of Natural Products for Medicinal Chemistry
Current Medicinal Chemistry Design, Synthesis, Molecular Docking, and Anticancer Evaluation of Pyrazole Linked Pyrazoline Derivatives with Carbothioamide Tail as EGFR Kinase Inhibitors
Anti-Cancer Agents in Medicinal Chemistry Antioxidant Activity of Resveratrol Analogs
Letters in Drug Design & Discovery Treatment Outcomes of the Standardized Shorter MDR-TB Regimen Under Programmatic Setting: A Retrospective Study from a Tertiary Care Centre, India
Current Respiratory Medicine Reviews Anti-Arthritic Effects of Immunomodulatory Peptide Injected in Joints
Current Drug Delivery Plant Defensins and Defensin-Like Peptides - Biological Activities and Biotechnological Applications
Current Pharmaceutical Design DNA-Electrochemical Biosensors: AFM Surface Characterisation and Application to Detection of In Situ Oxidative Damage to DNA
Combinatorial Chemistry & High Throughput Screening Beyond Stressed Self: Evidence for NKG2D Ligand Expression on Healthy Cells
Current Immunology Reviews (Discontinued) Catheter Related Line Sepsis Resulting from Mycobacterium <i>chelonae</i> Infection in an Immunocompromised Host
Infectious Disorders - Drug Targets Exploring Pyrimidine Pharmacophore as Thymidine Monophosphate Kinase Inhibitors for Antitubercular Activity: A Review
Current Topics in Medicinal Chemistry Trace and Minor Element Concentrations in Aqueous Extract of the Herbal Medicinal Plants Tamarindus indica and Hibiscus sabdiffora
Current Nutrition & Food Science Alcohol Abuse and HIV Infection: Role of DRD2
Current HIV Research Epidemiology and Pathophysiology of Chronic Cough
Current Respiratory Medicine Reviews