Current Pharmaceutical Biotechnology

Zeno Foldes-Papp
Visiting Professor of Medical Biochemistry
HELIOS Clinical Center of Emergency Medicine
Department for Internal Medicine
Alte-Koelner-Strasse 9
D-51688 Koeln-Wipperfuerth
Germany

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Cell-Penetrating Peptides as Delivery Enhancers for Vaccine

Author(s): Yuhong Jiang, Man Li, Zhirong Zhang, Tao Gong, Xun Sun.

Abstract:

The poor permeability of cellular membrane is one of the principal hurdles of most drug administrations including vaccine system, consequently impairing drug efficiency. In order to address this natural barrier, cell-penetrating peptides (CPPs) have been developed to facilitate molecular cargos to enter cells. CPPs, generally short peptides with 5-30 amino acids, can be classified in to cationic, amphipathic and hydrophobic types according to physical-chemical properties. In this review, different processes of antigen uptake, subsequent processing and presentation of CPP-based vaccine are comprehensively summarized despite precise mechanisms are not still established. Some experimental factors such as cell types, concentration of CPPs and antigenic cargos have been reported to affect antigen uptake orientation. Moreover, this review discusses different antigenic cargos where CPPs can transport for vaccine delivery as well as the application of CPPs in vaccine system via different administration routes like transdermal, subcutaneous and mucosal immunization.

Keywords: Administration route, antigenic cargo, cell-penetrating peptide, vaccine delivery.

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Article Details

VOLUME: 15
ISSUE: 3
Year: 2014
Page: [256 - 266]
Pages: 11
DOI: 10.2174/1389201015666140813130114
Price: $58