A dual carbon-carbon bond formation between 2,3-dibromo-1,4-naphthoquinone and terminal alkynes in EtOH
was efficiently facilitated by a combination of catalysts e.g. 10%Pd/C-Cu-PPh3 affording a handy and single-step synthesis
of 2,3-diyne-1,4-naphthoquinones. The methodology afforded desired products possessing potential medicinal value in
acceptable yields. A probable mechanism accounting the dual C-C bond forming reaction has been proposed.
Keywords: 1, 4-naphthoquinone, alkyne, cytotoxicity, Pd/C, C-C bond.
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