Pd/C-mediated Synthesis of 2,3-diyne-1,4-naphthoquinone Derivatives via dual C-C Bond Forming Reaction in a Single Step

Title:Pd/C-mediated Synthesis of 2,3-diyne-1,4-naphthoquinone Derivatives via dual C-C Bond Forming Reaction in a Single Step

Volume: 3 Issue: 3

Author(s): E. Sailaja, S. Bhavani, D. Rambabu, M. V. Basaveswara Rao and Manojit Pal

Affiliation:

Keywords: 1, 4-naphthoquinone, alkyne, cytotoxicity, Pd/C, C-C bond.

Abstract: A dual carbon-carbon bond formation between 2,3-dibromo-1,4-naphthoquinone and terminal alkynes in EtOH was efficiently facilitated by a combination of catalysts e.g. 10%Pd/C-Cu-PPh₃ affording a handy and single-step synthesis of 2,3-diyne-1,4-naphthoquinones. The methodology afforded desired products possessing potential medicinal value in acceptable yields. A probable mechanism accounting the dual C-C bond forming reaction has been proposed.

Cite this article as:

Sailaja E., Bhavani S., Rambabu D., Rao V. Basaveswara M. and Pal Manojit, Pd/C-mediated Synthesis of 2,3-diyne-1,4-naphthoquinone Derivatives via dual C-C Bond Forming Reaction in a Single Step, Current Catalysis 2014; 3 (3) . https://dx.doi.org/10.2174/2211544703666140812232815