Pd/C-mediated Synthesis of 2,3-diyne-1,4-naphthoquinone Derivatives via dual C-C Bond Forming Reaction in a Single Step

Author(s): E. Sailaja, S. Bhavani, D. Rambabu, M. V. Basaveswara Rao, Manojit Pal.

Journal Name:Current Catalysis

Volume 3 , Issue 3 , 2014

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Abstract:

A dual carbon-carbon bond formation between 2,3-dibromo-1,4-naphthoquinone and terminal alkynes in EtOH was efficiently facilitated by a combination of catalysts e.g. 10%Pd/C-Cu-PPh3 affording a handy and single-step synthesis of 2,3-diyne-1,4-naphthoquinones. The methodology afforded desired products possessing potential medicinal value in acceptable yields. A probable mechanism accounting the dual C-C bond forming reaction has been proposed.

Keywords: 1, 4-naphthoquinone, alkyne, cytotoxicity, Pd/C, C-C bond.

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2014
Page: [310 - 315]
Pages: 6
DOI: 10.2174/2211544703666140812232815
Price: $58