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Letters in Drug Design & Discovery
ISSN (Print): 1570-1808
ISSN (Online): 1875-628X
VOLUME: 12
ISSUE: 1
DOI: 10.2174/1570180811666140812231321









Design, Synthesis and Antitubercular Evaluation of New 2-amino-5-(4- (benzyloxy)benzyl)thiophene-3-carboxylic Acid Derivatives. Part 3

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Author(s): Xiaoyun Lu, Jian Tang, Qidong You, Baojie Wan and Scott G. Franzblau
Pages 29-37 (9)
Abstract:
A series of 2-amino-5-(4-(benzyloxy)benzyl)thiophene-3-carboxylic acid derivatives was designed and synthesized. The derivatives were evaluated for antitubercular activity against M. tuberculosis ATCC 27294 using the Microplate Alamar Blue Assay (MABA). Among them, compound 8b exhibited the most potent activity with MIC value of 1.9 µM.
Graphical Abstract:
Keywords:
2-amino-5-(4-(benzyloxy)benzyl)thiophene-3-carboxylic acid derivatives, antitubercular activity, design and synthesis, MIC, microplate Alamar Blue Assay (MABA), tuberculosis.
Affiliation:
Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190, Kaiyuan Avenue,Science Park, Guangzhou 510530, China.