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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Design, Synthesis and Antitubercular Evaluation of New 2-amino-5-(4- (benzyloxy)benzyl)thiophene-3-carboxylic Acid Derivatives. Part 3

Author(s): Xiaoyun Lu, Jian Tang, Qidong You, Baojie Wan and Scott G. Franzblau

Volume 12, Issue 1, 2015

Page: [29 - 37] Pages: 9

DOI: 10.2174/1570180811666140812231321

Price: $65

Abstract

A series of 2-amino-5-(4-(benzyloxy)benzyl)thiophene-3-carboxylic acid derivatives was designed and synthesized. The derivatives were evaluated for antitubercular activity against M. tuberculosis ATCC 27294 using the Microplate Alamar Blue Assay (MABA). Among them, compound 8b exhibited the most potent activity with MIC value of 1.9 µM.

Keywords: 2-amino-5-(4-(benzyloxy)benzyl)thiophene-3-carboxylic acid derivatives, antitubercular activity, design and synthesis, MIC, microplate Alamar Blue Assay (MABA), tuberculosis.

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