Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157
USA

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Role of Signaling Pathways in Mesenchymal Stem Cell Differentiation

Author(s): Birru Bhaskar, Naveen Kumar Mekala, Rama Raju Baadhe, Parcha Sreenivasa Rao.

Abstract:

Mesenchymal Stem Cells (MSCs) are self-renewing cells with ability to differentiate into organized, functional network of cells. In recent past research in developing clinical applications for MSCs has increased significantly. MSCs exhibit multi potential proliferation, and are capable of differentiating into cartilage, bone, neuronal cells and adipocytes, etc. Signaling pathways, transcription factors and growth factors modulate the differentiation of MSCs into different cell lineages. Besides, physical factors may regulate the molecular differentiation of stem cells. The main theme of this paper is to review the signaling pathways related to bone morphogenetic proteins (BMPs), epidermal growth factors (EGF), transforming growth factors (TGF), wingless type MMTV integration site (wnt) proteins, fibroblastic growth factor (FGF), and transcriptional regulating factors significance in the MSCs differentiation.

Keywords: Differentiation, growth factors, mesenchymal stem cells (MSCs), signaling pathways.

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Article Details

VOLUME: 9
ISSUE: 6
Page: [508 - 512]
Pages: 5
DOI: 10.2174/1574888X09666140812112002
Price: $58