Potential Anticancer Agents. I. Synthesis of Isoxazole Moiety Containing Quinazoline Derivatives and Preliminarily in vitro Anticancer Activity
14 new structures of isoxazole-moiety-containing quinazoline derivatives(3a~3n) were synthesized for
the first time and characterized by IR, 1H NMR, 13C NMR, ESI-MS. Subsequently, their in vitro anticancer
activity against A549, HCT116 and MCF-7 cell lines was preliminarily evaluated using the MTT method. Among
them, most compounds showed good to excellent anticancer activity, especially 3d, 3i, 3k and 3m exhibited the
more potent anticancer activity against A549, HCT116 and MCF-7 cell lines, which can be regarded as the
promising drug candidates for development of anticancer drugs.
Keywords: Anticancer activity, isoxazole moiety, quinazoline derivatives, synthesis.
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