Ferroquine as an Oxidative Shock Antimalarial

Author(s): Daniel Dive, Christophe Biot.

Journal Name: Current Topics in Medicinal Chemistry

Volume 14 , Issue 14 , 2014

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Abstract:

Over the course of the development of the antimalarial ferroquine, we have developed many ideas about its specific mechanism of action. Those ideas have enabled us to propose several experiments to control the validity of these hypotheses concerning differences between ferroquine and chloroquine and their respective mechanisms of action. We have now established an ultimate theory reconciling the hydrogen bond and the redox mechanisms hypotheses of ferroquine and fitting a wider range of published experimental results.

Keywords: Malaria, ferroquine, mechanism of action, hydrogen bond, redox behavior.

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Article Details

VOLUME: 14
ISSUE: 14
Year: 2014
Page: [1684 - 1692]
Pages: 9
DOI: 10.2174/1568026614666140808122329
Price: $58

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