The search for antimalarial compounds continues to be an area of intensive investigation in medicinal chemistry.
This review presents the structural variations around the indolone-N-oxide core. From these pharmacomodulation
studies, new antiplasmodial agents with various structures have emerged. Most of the molecules generated from reduced
forms of the indolone scaffold have led to compounds with antiplasmodial properties. These results confirm the importance
of the redox reversibility of the bioreducible N=C bond in these series to obtain antimalarial activities.
Keywords: Antimalarials, hit identification, indolones, indolone-N-oxides, Plasmodium falciparum.
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