Cardiovascular & Hematological Disorders-Drug Targets

(Formerly Current Drug Targets - Cardiovascular & Hematological Disorders)

Garry X. Shen  
University of Manitoba
Winnipeg, MB


Phospholipid Transfer Protein in Diabetes, Metabolic Syndrome and Obesity

Author(s): Shucun Qin, Guohua Song, Yang Yu.


It has been reported that phospholipid transfer protein (PLTP) is an independent risk factor for human coronary artery disease. And metabolic tissues are important contributors to the systemic pools of PLTP protein. Consistently, PLTP mass and activity have been found to be elevated in the plasma of type 2 diabetes mellitus (T2DM) and obese patients. In this review, we summarized the recent progresses made in the PLTP research field and focused on the complexity of the implication of PLTP in obesity, insulin resistance and T2DM.

Keywords: Diabetes, metabolic syndrome, obesity, phospholipid transfer protein.

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Article Details

Year: 2014
Page: [149 - 153]
Pages: 5
DOI: 10.2174/1871529X1402140807144435
Price: $58