Recent Advances in Protein and Peptide Drug Delivery: A Special Emphasis on Polymeric Nanoparticles

Author(s): Ashaben Patel, Mitesh Patel, Xiaoyan Yang, Ashim K. Mitra.

Journal Name: Protein & Peptide Letters

Volume 21 , Issue 11 , 2014

Abstract:

Proteins and peptides are widely indicated in many diseased states. Parenteral route is the most commonly em- ployed method of administration for therapeutic proteins and peptides. However, requirement of frequent injections due to short in vivo half-life results in poor patient compliance. Non-invasive drug delivery routes such as nasal, transdermal, pulmonary, and oral offer several advantages over parenteral administration. Intrinsic physicochemical properties and low permeability across biological membrane limit protein delivery via non-invasive routes. One of the strategies to improve protein and peptide absorption is by delivering through nanostructured delivery carriers. Among nanocarriers, polymeric nanoparticles (NPs) have demonstrated significant advantages over other delivery systems. This article summarizes the application of polymeric NPs for protein and peptide drug delivery following oral, nasal, pulmonary, parenteral, transder- mal, and ocular administrations.

Keywords: Brain, hydrophobic ion-pairing (HIP) complex, nasal, ocular, parenteral, polymeric nanoparticles, protein and pep- tide drug delivery, pulmonary, transdermal.

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Article Details

VOLUME: 21
ISSUE: 11
Year: 2014
Page: [1102 - 1120]
Pages: 19
DOI: 10.2174/0929866521666140807114240
Price: $58

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