Synthesis and Biological Activity of Some New N1-(6-fluoro-4-oxoquinolin- 8-yl)amidrazones
Mohammed M. Abadleh,
Mustafa M. El-Abadelah,
Salim S. Sabri,
Qasem M.A. Abdallah,
Mohamed F. El-Badawy.
A selected set of new N 1- (6-fluoro-4-oxoquinolin-8-yl)amidrazone-3-carboxylates (8a_e) incorporating Npiperazines
and related congeners has been synthesized by reacting the hydrazonoyl chloride, derived from 8-amino-6-
fluoro-4-oxoquinloine-3-carboxylate, with the appropriate sec-cyclic amine. Their suggested structures are supported by
elemental analysis, 1H NMR, 13C NMR and ESI-HRMS spectral data. These novel compounds (8a_e) were screened for
their antitumor and antibacterial activity. While no significant antitumor activity was observed, compounds 8a, 8b and 8d
have shown moderate in vitro antibacterial activity against Gram positive bacteria cells. Unlike the others, compound 8a
has also shown to moderately inhibit the growth of Gram negative bacteria.
Keywords: N1-(4-Oxoquinolin-8-yl)hydrazonoyl chloride, nitrile imines, 1, 3-nucleophilic addition, amidrazones, antibacterial
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