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CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)
ISSN (Print): 1871-5273
ISSN (Online): 1996-3181
DOI: 10.2174/1871527313666140806155929      Price:  $58

Differential Up-Regulation of Ammonia Detoxifying Enzymes in Cerebral Cortex, Cerebellum, Hippocampus, Striatum and Liver in Hyperammonemia

Author(s): Elena A. Kosenko, Lyudmila A. Tikhonova, Vutukuri P. Reddy, Gjumrakch Aliev and Yury G. Kaminsky
Pages 1089-1095 (7)
In order to gain insight into the ammonia-detoxification mechanisms in the brain and liver tissues, we have investigated the effects of hyperammonemia in rats, in vivo, on the activity levels of a number of ammonia- and glutamate-metabolizing enzymes in mitochondria and the cytosolic fractions of the cerebral cortex, cerebellum, hippocampus, striatum and liver. In general, the ammonia metabolizing enzymes – glutaminase, glutamine synthetase, glutamate dehydrogenase, AMP deaminase, adenosine deaminase, as well as aspartate aminotransferase and alanine aminotransferase – are differentially upregulated in various brain and liver regions of the hyperammonemic rats, indicating that divergent ammonia-detoxification mechanisms are involved in the various brain regions and liver in acute hyperammonemia.
Ammonia detoxification, cerebellum, cerebral cortex, glutamate metabolism, hippocampus, hyperammonemia, striatum.
(Yury G. Kaminsky) Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290, Russia.