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CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)
ISSN (Print): 1871-5273
ISSN (Online): 1996-3181
VOLUME: 13
ISSUE: 6
DOI: 10.2174/1871527313666140806155929      Price:  $58









Differential Up-Regulation of Ammonia Detoxifying Enzymes in Cerebral Cortex, Cerebellum, Hippocampus, Striatum and Liver in Hyperammonemia

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Author(s): Elena A. Kosenko, Lyudmila A. Tikhonova, Vutukuri P. Reddy, Gjumrakch Aliev and Yury G. Kaminsky
Pages 1089-1095 (7)
Abstract:
In order to gain insight into the ammonia-detoxification mechanisms in the brain and liver tissues, we have investigated the effects of hyperammonemia in rats, in vivo, on the activity levels of a number of ammonia- and glutamate-metabolizing enzymes in mitochondria and the cytosolic fractions of the cerebral cortex, cerebellum, hippocampus, striatum and liver. In general, the ammonia metabolizing enzymes – glutaminase, glutamine synthetase, glutamate dehydrogenase, AMP deaminase, adenosine deaminase, as well as aspartate aminotransferase and alanine aminotransferase – are differentially upregulated in various brain and liver regions of the hyperammonemic rats, indicating that divergent ammonia-detoxification mechanisms are involved in the various brain regions and liver in acute hyperammonemia.
Keywords:
Ammonia detoxification, cerebellum, cerebral cortex, glutamate metabolism, hippocampus, hyperammonemia, striatum.
Affiliation:
(Yury G. Kaminsky) Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290, Russia.