Is Human Immunodeficiency Virus-Mediated Dementia an Autophagic Defect that Leads to Neurodegeneration?

Author(s): Eleonora Passeri, Italo Mocchetti, Charbel Moussa.

Journal Name: CNS & Neurological Disorders - Drug Targets

Volume 13 , Issue 9 , 2014

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Abstract:

Autophagy is a cellular process that mediates selective degradation of cellular components in lysosomes. Autophagy may protect against neuronal apoptosis, which is induced in a number of neurodegenerative diseases. Thus, compounds that modulate autophagy could be beneficial to treat neurological disorders characterized by apoptosis such as Parkinson’s and Alzheimer’s diseases, as well as human-immunodeficiency virus-dementia complex. In this paper, we review new and old evidence on the role of autophagy in neuronal cell survival and we present evidence that humanimmunodeficiency virus may have adapted strategies to alter autophagic pathways in neurons. Moreover, we discuss the usefulness of drugs that facilitate autophagic clearance of proteins that are associated with neurodegeneration.

Keywords: Autophagy, apoptosis, beclin-1, gp120, lysosomes, Parkin.

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Article Details

VOLUME: 13
ISSUE: 9
Year: 2014
Page: [1571 - 1579]
Pages: 9
DOI: 10.2174/1871527313666140806125841
Price: $58

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