Depression is an affective disorder characterized by hallucination, delusion and increased
social risk and is estimated to affect approximately 20 % of the population at some point during the
lifetime. As per World Health Organization (WHO) it is predicted to be the leading cause of burden
of disease by 2030. Effects of currently available antidepressants have explained the monoamine
hypothesis of depression, which proposes that impaired release of serotonin, noradrenaline and
dopamine, are thought to be responsible for the development of depressive symptoms. However,
these drugs are not specific for their action, as they also inhibit other enzymes; this explains the side
effects/drug interactions associated with these agents. The present review will familiarize the readers
with novel targets being identified for depression which will be certainly beneficial for researcher,
academician for the development of drugs for the management of depression and related behavior.
Keywords: Cholinergic receptors, cocaine and amphetamine regulated transcript peptide, depression, histaminergic receptors,
N-methyl-D-aspartate, oxidative stress, substance P.
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