Lipid Nanoformulations for Oral Delivery of Bioactives: An Overview
Ranjana Gupta, Anant Agrawal, Md. Meraj Anjum, Harinath Dwivedi, Koshy M. Kymonil and Shubhini A. Saraf
Affiliation: Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, India.
Oral drug delivery has always been considered the preferred route of drug administration. Nano-formulations
are now constantly being researched for better absorption, higher bioavailability and greater therapeutic efficacy. Lipid
based nanoformulations have found much favour with the formulation scientist due to their relatively higher safety profile
and enhancement of bioavailability. These delivery systems are also able to protect the bioactives or drugs from the
vagaries of the gastrointestinal tract. They also aid in the absorption of hydrophobic drugs which are entrapped in lipid
matrices. Lipid excipients have been known to reduce efflux which is P-glycoprotein mediated and also to increase the
bioavailability of bioactives which are given through the oral route.
In the last 20 years, about a thousand articles and reviews about oral lipid carriers have been reported. Many dosage forms
have been made by modifying liposome, sometimes to overcome a disadvantage and at other times to modify the dosage
form in such a manner so as to suit the requirement of the drug molecules. Various other lipidic drug delivery systems
also exist which are not vesicular but being made of lipids, are equally useful for delivering lipophilic drugs. Although a
Lipid Formulation Classification System exists, but there is no exhaustive review which discusses the entire lipid based,
oral nanoformulations. The present review envisages discussing the various types of oral, lipid, nanosized, delivery
systems available, so that an insight is gained into all these carriers, and the formulation scientist can make a judicious
decision regarding choice of a lipid based carrier.
Keywords: Drug delivery, lipoidal, lipophilic, nanoparticles, vesicular.
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