A Discussion of MicroRNAs in Cancers
MicroRNAs (miRNAs) comprise an important class of small single-stranded non-coding RNAs that regulate
several important biological processes, including cell differentiation, growth, and apoptosis. The dysregulations of
miRNAs are usually correlated with several diseases because of their regulatory functions in organisms. Over the past few
years, miRNAs are often observed to be aberrantly expressed in cancers, indicating their potential correlations with cancer
pathogenesis. Recently, evidence has increased to prove this assumption. Further investigations show that miRNAs are
involved extensively in various cancer cell processes on the molecular level, including promotions of cancer cell
development. Considering the important functions of miRNAs in cancer development, investigating the relationship
between miRNAs and cancers can lead to a better understanding of the latter. Therefore, this review summarizes recent
developments from related studies, particularly focusing on the functions of miRNAs and their potential applications as
therapeutic strategies for cancers.
Keywords: Cancer, microRNAs, oncogenes, prognosis, tumor suppressors.
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