Recent Advances in the Synthesis of Organic Compounds to Combat Neglected Tropical Diseases

Recent Advances in the Synthesis of Organic Compounds to Combat Neglected Tropical Diseases

Indexed in: EBSCO.

The World Health Organization (WHO) has reported 14 diseases that are occurring exclusively in tropical areas. Most of these diseases are infectious and mainly affect poor populations. Some of ...
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LYMPHATIC FILARIASIS Therapeutic Arsenal and Drug Discovery for Lymphatic Filariasis from a Synthetic Point of View

Pp. 149-171 (23)

Gabriela Bianchi dos Santos, Ana Patrícia Yatsuda Natsui and Flavio da Silva Emery

Abstract

Lymphatic filariasis (LF) is one of the most devastating neglected diseases in terms of social and economic impact, disabling and disfiguring infected individuals. The infection occurs by parasitic filarial nematode worms that are transmitted between humans by blood-sucking insects. These parasites are known to have affected individuals in 81 countries, mostly in developing areas. Despite the epidemiological importance of this disease, current therapies have low effectiveness and a combined therapy has been adopted as the standard treatment. To interrupt transmission, the WHO recommends an annual mass drug distribution in endemic areas; however, this annual mass drug distribution program has resulted in an increase in nematode resistance. This type of program also depends on the availability of the required drugs, such as diethylcarbamazine, ivermectin, and albendazole. Some aspects of the production of these drugs are described in this chapter. Although clinically well characterized, there is an urgent need for innovative drugs for the treatment of neglected tropical diseases, and recent findings from structural chemistry studies could lead to safe, effective, and lowcost treatments for LF infection.

Keywords:

Lymphatic filariasis, filariae, macrolides, albendazole, DEC, drug discovery.

Affiliation:

Department of Pharmaceutical Sciences, Facult of Pharmaceutical Sciences of Ribeirão Preto - São Paulo University, Campus USP, Av do Café s/n - Monte Alegre, Ribeirão Preto/SP - 14040-903, Brazil.