Recent Advances in the Synthesis of Organic Compounds to Combat Neglected Tropical Diseases

Recent Advances in the Synthesis of Organic Compounds to Combat Neglected Tropical Diseases

Indexed in: EBSCO.

The World Health Organization (WHO) has reported 14 diseases that are occurring exclusively in tropical areas. Most of these diseases are infectious and mainly affect poor populations. Some of ...
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LEISHMANIASIS An Overview of New Synthetic Antileishmanial Candidates

Pp. 63-121 (59)

Nubia Boechat and Luiz Carlos da Silva Pinheiro

Abstract

Leishmaniasis is considered by the World Health Organization to be one of the world’s most neglected diseases. The current drugs used to treat leishmaniasis were developed more than 40 years ago and are toxic. In addition, they generate resistance, and coinfection with the AIDS virus has worsened the situation of this disease. The purpose of this chapter is to review the various synthetic compounds described between 2002 and 2012 that have been tested against Leishmania spp. and that could be considered possible prototypes for treating this disease. Compounds were organized into 20 chemical classes.

Keywords:

Leishmaniasis, prototypes, synthesis.

Affiliation:

Oswaldo Cruz Foundation – Fiocruz, Institute of Drug Technology - Farmanguinhos, Department of Organic Synthesis. 21041-250, Rio de Janeiro, RJ, Brazil.