CHAGAS DISEASE An Overview of Recent Advances in the Search for Synthetic Organic Compounds with Trypanocidal Activity
Pp. 3-31 (29)
Ana Camila Micheletti, Edson dos Anjos dos Santos and Felicia Megumi Ito
Chagas disease was discovered over 100 years ago, and continues to be a
major public health problem, with 16 to 18 million people infected with Trypanososma
cruzi, its causative agent, and 21,000 deaths associated with this disease every year.
Nifurtimox (Nfx) and benznidazole (Bnz) are even today the only clinically available
drugs for the chemotherapy of Chagas disease, but they show significant side effects,
involve long-term treatment and there are other problems, like emergence of resistant
strains. This chapter aims to highlight recent contributions from the organic synthesis
field on developing new compounds with trypanocidal activity, including discussion on
important structural features and molecular targets.
Chagas disease, antichagasic activity, organic synthesis, trypanocidal
Federal University of Mato Grosso do Sul, Institute of Chemistry, Av. Senador Filinto Muller, 1555, 79074-460, Campo Grande-MS, Brazil.