Synthesis and Biological Evaluation of Some Novel 10H-Phenothiazines, their Sulfones and Nucleosides as Possible Antimicrobial Agents

Author(s): Naveen Gautam, Anjali Guleria, Mukesh K. Sharma, Sudesh K. Gupta, Arun Goyal, D.C. Gautam.

Journal Name:Current Bioactive Compounds

Volume 10 , Issue 3 , 2014

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Abstract:

Since the time of Ehrlich (1854-1915) the antimicrobial activity of synthetic, non-chemotherapeutic compounds like phenothiazines and methylene blue, has been known. This article reports synthesis of some new 10Hphenothiazines, their sulfones and nucleosides, which have shown antimicrobial activity to a good extent against some selected strains of fungi, Gram positive and Gram negative bacteria leading us to a possibly potent class of antimicrobial agents. Reported 10H-phenothiazines were prepared using smiles rearrangement. These synthesized 10H-phenothiazines yield sulfones on oxidation with 30% hydrogen peroxide in glacial acetic acid and form nucleosides when treated with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate (sugar). Structural assignment is done by spectral and elemental investigations.

Keywords: Antimicrobial activity, nucleosides, 10H-phenothiazines, smiles rearrangement, sulfones.

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Article Details

VOLUME: 10
ISSUE: 3
Year: 2014
Page: [189 - 195]
Pages: 7
DOI: 10.2174/1573407210666140728174315
Price: $58