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Letters in Drug Design & Discovery
ISSN (Print): 1570-1808
ISSN (Online): 1875-628X
VOLUME: 12
ISSUE: 1
DOI: 10.2174/1570180811666140725185713









Design, Synthesis and Biological Evaluation of Benzimidazole-pyridine- Piperidine Hybrids as a New Class of Potent Antimicrobial Agents

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Author(s): Kothapally. Beulah, Akula Ravi Kumara, Boddupally Peda Venkat Lingaiah, Pamulaparthy Shanthan Rao, Banda Narsaiah, Aaramadaka Sunil Kumar Reddy and Upadhyayula Surya Narayana Murty
Pages 38-45 (8)
Abstract:
A series of novel benzimidazole-pyridine-piperidine hybrids was synthesized in good yields and characterized by spectral and elemental analyses. The compounds 4a-h and 5a-c were evaluated for their in vitro antibacterial activity against gram-positive organisms viz., Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, gramnegative organisms viz., Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia and also against fungal strains like Candida albicans, Saccharomyces cervisiae of yeasts, Aspergillus flavus, Aspergillus niger according to the CLSI Standard Protocol. Compound 5a showed promising activity against all tested organism excluding Bacillus subtilis when compared to standard drugs.
Graphical Abstract:
Keywords:
2-substituted benzimidazole, antibacterial activity, antifungal activity, ethyl-piperidine-4-carboxylic acid, hybrid molecules, pyridine.
Affiliation:
Fluoroorganic Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad- 500007, India.