Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Design, Synthesis and Biological Evaluation of Benzimidazole-pyridine- Piperidine Hybrids as a New Class of Potent Antimicrobial Agents

Author(s): Kothapally. Beulah, Akula Ravi Kumara, Boddupally Peda Venkat Lingaiah, Pamulaparthy Shanthan Rao, Banda Narsaiah, Aaramadaka Sunil Kumar Reddy, Upadhyayula Surya Narayana Murty.

Graphical Abstract:


Abstract:

A series of novel benzimidazole-pyridine-piperidine hybrids was synthesized in good yields and characterized by spectral and elemental analyses. The compounds 4a-h and 5a-c were evaluated for their in vitro antibacterial activity against gram-positive organisms viz., Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, gramnegative organisms viz., Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia and also against fungal strains like Candida albicans, Saccharomyces cervisiae of yeasts, Aspergillus flavus, Aspergillus niger according to the CLSI Standard Protocol. Compound 5a showed promising activity against all tested organism excluding Bacillus subtilis when compared to standard drugs.

Keywords: 2-substituted benzimidazole, antibacterial activity, antifungal activity, ethyl-piperidine-4-carboxylic acid, hybrid molecules, pyridine.

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Article Details

VOLUME: 12
ISSUE: 1
Year: 2015
Page: [38 - 45]
Pages: 8
DOI: 10.2174/1570180811666140725185713