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Letters in Drug Design & Discovery
ISSN (Print): 1570-1808
ISSN (Online): 1875-628X
Epub Full Text Article
DOI: 10.2174/1570180811666140725185713      Price:  $95

Design, Synthesis and Biological Evaluation of Benzimidazole-Pyridine-Piperidine Hybrids as a new class of potent Antimicrobial Agents

Author(s): Kothapally Beulah, Akula Ravi Kumar, Boddupally Peda Venkat Lingaiah, Pamulaparthy Shanthan Rao, Banda Narsaiah, Aaramadaka Sunil Kumar Reddy and Upadhyayula Surya Narayana Murty
A series of novel benzimidazole-pyridine-piperidine hybrids were synthesized in good yields and characterized by spectral and elemental analyses. The compounds 4a-h and 5a-c were evaluated for their in vitro antibacterial activity against gram-positive organisms viz., Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, gram-negative organisms viz., Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia and also against fungal strains like Candida albicans, Saccharomyces cervisiae of yeasts, Aspergillus flavus, Aspergillus niger was done according to CLSI Standard Protocol. Compound 5a showed promising activity against all tested organism exclude Bacillus subtilis when compared to standard drugs.
2-substituted benzimidazole, antibacterial activity, antifungal activity, ethyl-piperidine-4-carboxylic acid, hybrid molecules, pyridine
Fluoroorganic Division, CSIR-Indian Institute of Chemical Technology Tarnaka, Hyderabad- 500007 India.