Recent Advances in Medicinal Chemistry

Volume: 1

Indexed in: Book Citation Index, Science Edition; BIOSIS Previews, EBSCO.

Recent advances in Medicinal Chemistry is a book series focused on leading-edge research on developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, ...
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Preclinical Studies of Saponins for Tumor Therapy

Pp. 272-302 (31)

Christopher Bachran, Silke Bachran, Mark Sutherland, Diana Bachran and Hendrik Fuchs

Abstract

Various saponins, plant glycosides with favorable anti-tumorigenic properties, have been used to inhibit tumor cell growth by cell cycle arrest and apoptosis with IC50 values of up to 0.2 μM. We describe several groups of saponins (dioscins, saikosaponins, julibrosides, soy saponins, ginseng saponins and avicins) currently investigated for their use in tumor therapy. We focus on cellular and systemic mechanisms of tumor cell growth inhibition both in vitro and in vivo, combinational approaches with saponins and conventional tumor treatment strategies, and successful syntheses of saponins. The increasing interest in saponins for tumor therapy is very promising for the future development of sophisticated anti-cancer drugs.

Keywords:

Cancer, cytotoxicity, glycoside, saponin, steroid, tumor therapy, triterpenoid.

Affiliation:

Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, D-13353 Berlin, Germany.