Recent Advances in Medicinal Chemistry

Volume: 1

Indexed in: EBSCO.

Recent advances in Medicinal Chemistry is a book series focused on leading-edge research on developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, ...
[view complete introduction]

US $
30

*(Excluding Mailing and Handling)



Rho-GTPases and Statins: A Potential Target and a Potential Therapeutic Tool Against Tumors?

Pp. 209-245 (37)

Ivana Campia, Sophie Doublier, Elisabetta Aldieri, Amalia Bosia, Dario Ghigo and Chiara Riganti

Abstract

Rho GTPases, which control processes such as cell proliferation and cytoskeleton remodeling, are often hyperexpressed in tumors. Several members, such as RhoA/B/C, must be isoprenylated to interact with their effectors. Statins, by inhibiting the synthesis of prenyl groups, may affect RhoA/B/C activity and represent a promising tool in anticancer therapy.

Keywords:

Cancer, chemotherapy, isoprenylation, rho GTPases, statins.

Affiliation:

Department of Oncology, Via Santena 5/bis, 10126 Torino, Italy.