Rho-GTPases and Statins: A Potential Target and a Potential Therapeutic Tool Against Tumors?
Pp. 209-245 (37)
Ivana Campia, Sophie Doublier, Elisabetta Aldieri, Amalia Bosia, Dario Ghigo and Chiara Riganti
Rho GTPases, which control processes such as cell proliferation and
cytoskeleton remodeling, are often hyperexpressed in tumors. Several members, such as
RhoA/B/C, must be isoprenylated to interact with their effectors. Statins, by inhibiting
the synthesis of prenyl groups, may affect RhoA/B/C activity and represent a promising
tool in anticancer therapy.
Cancer, chemotherapy, isoprenylation, rho GTPases, statins.
Department of Oncology, Via Santena 5/bis, 10126 Torino, Italy.