Bacterial FabH: Towards the Discovery of New Broad-Spectrum Antibiotics
Pp. 131-158 (28)
Yunierkis Pérez-Castillo, Matheus Froeyen, Ann Nowé and Miguel Ángel Cabrera-Pérez
The emergence of drug resistant strains of important human pathogens has
made urgent the necessity of finding new targets and novel antimicrobial agents. One of
the most promising targets is FabH. Here we summarize the progress made in the design
of FabH inhibitors and the role played by the 3D-structure of the enzyme as well as by
the modeling studies in the design of new FabH inhibitors.
Drug design, FabH, FAS, FabH inhibitors.
Molecular Simulation & Drug Design Group. Centro de BioactivosQuímicos. Universidad Central de Las Villas, Santa Clara, 54830, Villa Clara, Cuba.