Recent Advances in Medicinal Chemistry

Volume: 1

Indexed in: Book Citation Index, Science Edition; BIOSIS Previews, EBSCO.

Recent advances in Medicinal Chemistry is a book series focused on leading-edge research on developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, ...
[view complete introduction]

US $
30

*(Excluding Mailing and Handling)



New Functions of Old Drugs: Aureolic Acid Group of Anti- Cancer Antibiotics and Non-Steroidal Anti-Inflammatory Drugs

Pp. 3-55 (53)

Hirak Chakraborty, Pukhrambam Grihanjali Devi, Munna Sarkar and Dipak Dasgupta

Abstract

Non-steroidal anti-inflammatory drugs and aureolic acid group of anti-cancer drugs belong to the class of generic drugs. Research with some members of these two groups of drugs in different laboratories has unveiled functions other than those for which they were primarily developed as drugs. Here we have reviewed the molecular mechanism behind the multiple functions of these drugs that might lead to employ them for treatment of diseases in addition to those they are presently employed. The distinct advantage of using old drugs for alternate functions lies in their well-studied Absorption Distribution Metabolism Excretion and Toxicity (ADMET) profile.

Keywords:

Alternate functions, alzheimer disease, anti-cancer, aureolic acid group, COX dependent and COX independent pathways, Drug repositioning, metal chelation, non steroidal anti-inflammatory drugs, painkillers.

Affiliation:

Chemical Sciences Division, Biophysics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700 064, India.