Mesenchymal Stem Cells Regulate Cytoskeletal Dynamics and Promote Cancer Cell Invasion Through Low Dose Nitric Oxide

Author(s): L. Zhang, J. Sun, Z. Liu, Y. Dai, Z. Luo, X. Jiang, Z. Li, Y. Li, P. Cao, Y. Zhou, Z. Zeng, A. Tang, X. Li, X. Li, J. Xiang, G. Li.

Journal Name: Current Molecular Medicine

Volume 14 , Issue 6 , 2014

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Abstract:

Bone marrow-derived mesenchymal stem cells (BMSCs) can be recruited to tumor sites and integrate into the stroma of tumors. When co-cultured with BMSCs, otherwise weakly metastatic nasopharyngeal carcinoma cells (NPC) showed improved metastatic ability. BMSCs in the tumor environment displayed the characteristics of macrophages. Nitric oxide produced by BMSCs in tumor environment could translocate caldesmon to podosome in Ca2+/calmodulin manner and promoted metastatic ability of NPC cells through invadopodia formation, with which the NPC cells degrade the extracellular matrix. Thus, we concluded that the BMSCs promoted cell migration and invasion through nitric oxide-induced paracrine signals.

Keywords: Bone marrow-derived mesenchymal stem cells, invadopodia, matrix degradation, metastasis, nasopharyngeal carcinoma, nitric oxide.

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2014
Page: [749 - 761]
Pages: 13
DOI: 10.2174/1566524014666140724102301
Price: $58

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