A Review on Antiproliferative and Apoptotic Activities of Natural Honey
Saravana Kumar Jaganathan,
Muthu Vignesh Vellayappan,
Manjesh Kumar Asokan,
Aruna Priyadharshni Subramanian,
Agnes Aruna John,
Saiful Izwan Abd Razak,
Recent statistics revealed that cancer is one among the main reasons for death throughout the world. Several
treatments are available but still there is no cure when it is detected at late stages. One of the treatment modes for cancer is
chemotherapy which utilizes anticancer drugs in order to eradicate the cancer cells by apoptosis. Apoptosis is a
programmed cell death through which body maintains homeostasis or kills cancer cells by utilizing its cell machinery.
Recent researches have concluded that dietary agents have a putative role in instituting apoptosis of cancer cells. Honey, one of the
victuals rich in antioxidants, has a long-standing exposure to humans and its role in cancer prevention and treatment is a topic of current
interest. Various researchers have been experimenting honey against different cancers and provided valuable insights about the apoptosis
induced by the honey. This review will highlight the recent findings of apoptotic mechanism involved in different cancer cells. Further it
also reports antitumor activity of honey in some animal models. Hence it is high-time to initiate more preclinical trials as well as clinical
experiments which would further add to the knowledge of anticancer nature of honey and also endorse honey as a potential candidate in
the war against cancer.
Keywords: Antiproliferative, antitumor, apoptosis, cancer, honey.
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