Login

Journal Image
Letters in Drug Design & Discovery
ISSN (Print): 1570-1808
ISSN (Online): 1875-628X
VOLUME: 11
ISSUE: 10
DOI: 10.2174/1570180811666140717185937      Price:  $58









Synthesis and Evaluation of Bis-pyrazoline Derivatives as Potential Antimicrobial Agents

img
Author(s): Mehlika Dilek Altıntop, Usama Abu Mohsen, Hulya Karaca, Zerrin Canturk and Ahmet Ozdemir
Pages 1199-1203 (5)
Abstract:
In the present study, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-arylthiazol-2-yl)] derivatives (3a-h) were obtained via the reaction of 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1- carbothioamide] (2) with phenacyl bromides. The synthesized compounds were investigated for their antimicrobial activity against various bacteria and Candida species. Among these derivatives, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5- dihydro-1H-pyrazole-1-(4-(4-chlorophenyl)thiazol-2-yl)] (3b) and 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1Hpyrazole- 1-(4-(4-methoxyphenyl)thiazol-2-yl)] (3d) showed notable antimicrobial activity.
Graphical Abstract:
Keywords:
Antimicrobial activity, pyrazole, thiazole.
Affiliation:
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.