Synthesis and Evaluation of Bis-pyrazoline Derivatives as Potential Antimicrobial Agents

Title:Synthesis and Evaluation of Bis-pyrazoline Derivatives as Potential Antimicrobial Agents

Volume: 11 Issue: 10

Author(s): Mehlika Dilek Altıntop, Usama Abu Mohsen, Hulya Karaca, Zerrin Canturk and Ahmet Ozdemir

Affiliation:

Keywords: Antimicrobial activity, pyrazole, thiazole.

Abstract: In the present study, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-arylthiazol-2-yl)] derivatives (3a-h) were obtained via the reaction of 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1- carbothioamide] (2) with phenacyl bromides. The synthesized compounds were investigated for their antimicrobial activity against various bacteria and Candida species. Among these derivatives, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5- dihydro-1H-pyrazole-1-(4-(4-chlorophenyl)thiazol-2-yl)] (3b) and 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1Hpyrazole- 1-(4-(4-methoxyphenyl)thiazol-2-yl)] (3d) showed notable antimicrobial activity.

Cite this article as:

Dilek Altıntop Mehlika, Abu Mohsen Usama, Karaca Hulya, Canturk Zerrin and Ozdemir Ahmet, Synthesis and Evaluation of Bis-pyrazoline Derivatives as Potential Antimicrobial Agents, Letters in Drug Design & Discovery 2014; 11 (10) . https://dx.doi.org/10.2174/1570180811666140717185937