Spectroscopic Characterization of a Pyridine Alkaloid from an Endophytic Strain of the Fusarium incarnatum-equiseti Species Complex

Author(s): Monica Scognamiglio, Rosario Nicoletti, Severina Pacifico, Brigida D'Abrosca, Antonio Fiorentino.

Journal Name:Current Bioactive Compounds

Volume 10 , Issue 3 , 2014

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Abstract:

Chemical investigation of the endophytic strain A1021B ascribed to the Fusarium incarnatum-equiseti species complex led to the isolation of a novel pyridine alkaloid related to fusaric acid. The structure was elucidated by 1D and 2D NMR experiments (1H, 13C, COSY, HSQC, CIGAR-HMBC, H2BC). The compound induced cytotoxic effects on six human cancer cell lines (SK-N-BE(2)-C, SH-SY5Y, A549, HepG2, HeLa, and MCF-7).

Keywords: Cytotoxicity, endophyte, fusarinol, Fusarium incarnatum-equiseti, NMR analysis.

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Article Details

VOLUME: 10
ISSUE: 3
Year: 2014
Page: [196 - 200]
Pages: 5
DOI: 10.2174/1573407210666140716163923
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