Design and Development of Preservative Free Herbal Dosage Forms
T.M. Pramod Kumar,
U. Aravind Padiyar,
This review focuses on principles of product preservation, preservatives, and novel technologies for the future
development of preservative free herbal products. The purpose of this study was to determine the amount of preservatives
in pharmaceutical products as some recent studies reported serious side effects associated with the ingestion of these
substances. The principles involved were asepsis and removal of microorganisms — both static and cidal effects. Some of
the novel technologies of asepsis are high pressure processing, pulsed electric field treatment and non-thermal
technologies including ultraviolet processing. All relevant literature databases were searched upto 2011. Majority of the
human, animal, in vitro studies, and reviews were included. Preservative free dosage forms must be formulated for the
reduction in side effects and hence a healthier mankind.
Keywords: High pressure shift freezing, osmotic filtration, parabens, pasteurization, pulsed electric technique.
Rights & PermissionsPrintExport