Antimalassezia Activity of Medicated Antidandruff Shampoo Formulated with Microwave Dried Garlic Powder with Improved Allicin Stability
Deokar Gitanjali, Pethkar Prajakta, Bakshe Swati, Erande Kiran and Bhambar Rajendra
Affiliation: Bhujbal Knowledge City, MET’s Institute of Pharmacy, Adgoan, Nashik-422003, Maharashtra, India.
Keywords: Allium Sativum, allicin, malassezia furfur, medicated shampoo, microwave drying, minimum inhibitory
Dandruff is a very common non- inflammatory scalp condition caused by lipophilic, dimorphic yeast
malassezia furfur. Garlic (Allium Sativum, Liliacae) contains allicin which is its potential principle constitutent that posses
antiviral, antifungal, and parasitic activity. Content of allicin in microwave assisted garlic powder and aqueous garlic
extract was found to be 1242.29 μg/gm of garlic powder and 552.26 μg/gm of garlic bulbs respectively by Solid phase
extraction–UV method. Minimum inhibitory concentrations of microwave assisted garlic powder and aqueous garlic
extract was found to be 268.33 μg /ml and 249.6 μg /ml respectively. From the minimum inhibitory concentration (MIC)
obtained, the microwave assisted garlic powder and aqueous garlic extract were then incorporated at different percentages
into shampoo formulations. The shampoo formulations were evaluated for two months at room temperature and 40C.
Aqueous extract containing shampoo showed inhibitory action for 1 week (7 days) but growth was observed after 2
weeks(14 days) at both temperature conditions. Microwave assisted garlic powder containing shampoo when kept at 40C
showed inhibitory action up to 4 weeks (28 days) but growth was observed after 5 weeks (35 days) and shampoo
formulations kept at room temperature showed inhibitory action up to 5 weeks(35 days) but growth was observed after 6
weeks(42days). Study shows that microwave drying technique helps in improving stability of allicin. Whereas Storage at
refrigerator temperature has no role in stability improvement of allicin in the formulation.
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