Current Pharmaceutical Biotechnology

Zeno Foldes-Papp
Visiting Professor of Medical Biochemistry
HELIOS Clinical Center of Emergency Medicine
Department for Internal Medicine
Alte-Koelner-Strasse 9
D-51688 Koeln-Wipperfuerth
Germany

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Resveratrol as a Gene Regulator in the Vasculature

Author(s): Ning Xia, Ulrich Forstermann and Huige Li

Affiliation: Department of Pharmacology, University Medical Center, Johannes Gutenberg University, Obere Zahlbacher Str. 67, 55131 Mainz, Germany.

Keywords: Gene regulation, nitric oxide, oxidative stress, resveratrol, vascular inflammation.

Abstract:

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) possesses multiple protective properties in the vasculature, including anti-oxidative and anti-inflammatory effects and improvement of endothelial function. A substantial part of these effects is attributable to gene expression changes induced by the compound. Resveratrol can activate the NAD-dependent deacetylase sirtuin 1 (SIRT1), leading to deacetylation of SIRT1 target molecules such as NF-kB and forkhead box O (FOXO) transcription factors. The inhibition of NF-kB by resveratrol reduces the expression of inflammation mediators. FOXO factors are implicated in the upregulation of antioxidant enzymes and the endothelial-type nitric oxide synthase. In addition, resveratrol upregulates a number of antioxidant enzymes by activating nuclear factor-E2-related factor-2 (Nrf2) and downregulates NADPH oxidases through yet known mechanisms.

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Article Details

VOLUME: 15
ISSUE: 4
Page: [401 - 408]
Pages: 8
DOI: 10.2174/1389201015666140711114450