Resveratrol as a Gene Regulator in the Vasculature
Ning Xia, Ulrich Forstermann and Huige Li
Pages 401-408 (8)
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) possesses multiple protective properties in the vasculature, including
anti-oxidative and anti-inflammatory effects and improvement of endothelial function. A substantial part of these effects
is attributable to gene expression changes induced by the compound. Resveratrol can activate the NAD-dependent
deacetylase sirtuin 1 (SIRT1), leading to deacetylation of SIRT1 target molecules such as NF-kB and forkhead box O
(FOXO) transcription factors. The inhibition of NF-kB by resveratrol reduces the expression of inflammation mediators.
FOXO factors are implicated in the upregulation of antioxidant enzymes and the endothelial-type nitric oxide synthase. In
addition, resveratrol upregulates a number of antioxidant enzymes by activating nuclear factor-E2-related factor-2 (Nrf2)
and downregulates NADPH oxidases through yet known mechanisms.
Gene regulation, nitric oxide, oxidative stress, resveratrol, vascular inflammation.
Department of Pharmacology, University Medical Center, Johannes Gutenberg University, Obere Zahlbacher Str. 67, 55131 Mainz, Germany.