Ricin Toxin

`Ricin Toxin’ brings together a collection of in depth and cutting edge reviews that focus on the current understanding of ricin toxins. This e-book provides a historical background, innovations in ...
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Anti-Ricin Protective Monoclonal Antibodies

Pp. 145-158 (14)

Wei-Gang Hu, Junfei Yin, Damon Chau, Charles C. Hu and John W. Cherwonogrodzky

Abstract

Development of anti-ricin protective monoclonal antibodies (mAbs) started in the early 1980s. Much progress has been made since then. Antibodies possess great potential for development as antidotes against toxins. These can be used either prophylactically to prevent, or therapeutically to treat, toxin-mediated intoxications in an emergency situation. Unlike many other therapeutic products, antibodies offer unique and high target specificity, and long half-life in serum. There are several mAbs which are currently in the discovery stage for medical countermeasures against ricin intoxication. This review summarizes these mAbs, including their anti-ricin mechanism, generation, and efficacies in vivo.

Keywords:

Ricin, protective, monoclonal antibodies, chimerization, humanization.

Affiliation:

DRDC, Suffield Research Centrem, Box 4000, Station Main, Medicine Hat, Alberta T1A 8K6, Canada.