Abstract
About 1 billion cardiomyocytes are lost in heart disease such as myocardial infarction; the regeneration capacity of cardiomyocytes is extremely low and the heart is unable to fix this damage naturally. In the past 20 years, multiple cells, such as skeletal myoblasts, bone marrow-derived cells, cardiac progenitor cells and pluripotent stem cells have been utilized to test the efficacy on heart repair, but these cells show different kinds of drawbacks. Recent studies have revealed that concomitant transplantation of endothelial cells and stem cells can significantly improve the efficacy of cell based heart repair. In this review, we describe the progress on these studies with an emphasis on endothelial cell facilitated stem cell therapy. We also summarize the beneficial mechanisms of endothelial cells in cardiac repair and point out the potential challenges for endothelial cell-facilitated-cell therapy to be adopted for clinical application.
Keywords: Cardiac repair, endothelial cells, stem cells.
Current Stem Cell Research & Therapy
Title:Endothelial Cells Facilitate Cell-Based Cardiac Repair: Progress and Challenge
Volume: 9 Issue: 5
Author(s): Ping Yuan and Xin Ma
Affiliation:
Keywords: Cardiac repair, endothelial cells, stem cells.
Abstract: About 1 billion cardiomyocytes are lost in heart disease such as myocardial infarction; the regeneration capacity of cardiomyocytes is extremely low and the heart is unable to fix this damage naturally. In the past 20 years, multiple cells, such as skeletal myoblasts, bone marrow-derived cells, cardiac progenitor cells and pluripotent stem cells have been utilized to test the efficacy on heart repair, but these cells show different kinds of drawbacks. Recent studies have revealed that concomitant transplantation of endothelial cells and stem cells can significantly improve the efficacy of cell based heart repair. In this review, we describe the progress on these studies with an emphasis on endothelial cell facilitated stem cell therapy. We also summarize the beneficial mechanisms of endothelial cells in cardiac repair and point out the potential challenges for endothelial cell-facilitated-cell therapy to be adopted for clinical application.
Export Options
About this article
Cite this article as:
Yuan Ping and Ma Xin, Endothelial Cells Facilitate Cell-Based Cardiac Repair: Progress and Challenge, Current Stem Cell Research & Therapy 2014; 9 (5) . https://dx.doi.org/10.2174/1574888X09666140710100143
DOI https://dx.doi.org/10.2174/1574888X09666140710100143 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Anabolic Androgenic Steroid (AAS) Related Deaths: Autoptic, Histopathological and Toxicological Findings
Current Neuropharmacology Microbial Metabolomics
Current Genomics Searching for Phytoinsulins as Cardiovascular Protector in Metabolic Syndrome
Current Pharmaceutical Design The Metabolic Syndrome and Cardiovascular Risk
Current Diabetes Reviews Role of Endothelin in Uteroplacental Circulation and Fetal Vascular Function
Current Vascular Pharmacology Oleic Acid in Olive Oil: From a Metabolic Framework Toward a Clinical Perspective
Current Pharmaceutical Design Molecular Genetics of Left Ventricular Dysfunction
Current Molecular Medicine Effect of S-equol and Soy Isoflavones on Heart and Brain
Current Cardiology Reviews Effects of Music Therapy on Psychological Symptoms and Heart Rate Variability in Patients with Dementia. A Pilot Study
Current Aging Science Histamine-Dependent and -Independent Hypersensitivity Reactions to Contrast Media: The Impact of Antihistamines
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The Mediterranean Diet and Gastrointestinal Cancers Risk
Recent Patents on Food, Nutrition & Agriculture Stressing Conditions as Tools to Boost the Biosynthesis of Valuable Plant Natural Products
Recent Patents on Biotechnology Synthesis and Biological Evaluation of Atorvastatin Derivatives as Novel HMG-CoA Reductase Inhibitors
Letters in Drug Design & Discovery An Experimental and Theoretical Approach to Understand Fever, DENF & its Cure
Infectious Disorders - Drug Targets Nutritional Supplements Modulating Metabolic Syndrome Risk Factors and the Prevention of Cardiovascular Disease
Current Nutrition & Food Science MicroRNAs as Early Biomarkers in Obesity and Related Metabolic and Cardiovascular Diseases
Current Pharmaceutical Design Pharmaceutical Measures to Prevent Doxorubicin-Induced Cardiotoxicity
Mini-Reviews in Medicinal Chemistry Plasma Level of D-dimer is an Independent Diagnostic Biomarker for Deep Venous Thrombosis in Patients with Ischemic Stroke
Current Neurovascular Research Antiarrhythmic Potential of Drugs Targeting the Cardiac Ryanodine Receptor Ca<sup>2+</sup> Release Channel: Case Study of Dantrolene
Current Pharmaceutical Design Recent Advances in Developing K-Ras Plasma Membrane Localization Inhibitors
Current Topics in Medicinal Chemistry