Biomarkers of Immunity and Inflammation for use in Nutrition Interventions: International Life Sciences Institute European Branch Work on Selection Criteria and Interpretation
Philip C. Calder
Affiliation: Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, MP887 Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom.
In order to gain better insight into meaningful effects of nutrition on immune function, there is a need for
guidance on the assessment and interpretation of immune markers. However, there is no consensus as to which markers
best represent the various aspects of immunity, including acute, chronic or low-grade inflammation. International Life
Sciences Institute European Branch has commissioned several expert groups comprising individuals from different
backgrounds including academia, government and the food industry to prepare descriptive and guidance documents on
this topic. Two of these considered the markers of the immune response mainly in the context of host defence against
pathogens, two considered general markers of inflammation, and one focussed on chronic low-grade inflammation in
relation to overweight and obesity. This article describes the background to these documents and will summarise the
work, findings and recommendations of the expert groups.
Keywords: Biomarker, claim, diet, functional food, immune function, infection, inflammation, nutrition.
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