Ultrasound-promoted One-pot Synthesis of 2-Thioxo-dihydropyrimidine Derivatives Bearing Piperidinylamide Moiety

Author(s): Bao-Hua Chen, Ji-Tai Li, Rui-Jia Lan, Guo-Feng Chen.

Journal Name: Letters in Organic Chemistry

Volume 11 , Issue 9 , 2014

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Graphical Abstract:


A convenient and efficient one-pot synthesis of 2-thioxo-dihydropyrimidine derivatives bearing piperidinylamide moiety is described. The reactions were carried out in 81-91% yields via the condensation of 1-(piperidin-1- yl)butane-1,3-dione with aromatic aldehyde and thiourea in ethanol catalyzed by p-toluenesulfonic acid at room temperature under ultrasound irradiation. The advantages of this methodology are convenient operation, mild conditions, short reaction times and high yields.

Keywords: Catalysis, condensation, one-pot synthesis, piperidinylamide, 2-thioxo-dihydropyrimidine, ultrasound irradiation.

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Article Details

Year: 2014
Page: [643 - 650]
Pages: 8
DOI: 10.2174/1570178611666140707183047
Price: $58

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