Ultrasound-promoted One-pot Synthesis of 2-Thioxo-dihydropyrimidine Derivatives Bearing Piperidinylamide Moiety
A convenient and efficient one-pot synthesis of 2-thioxo-dihydropyrimidine derivatives bearing piperidinylamide
moiety is described. The reactions were carried out in 81-91% yields via the condensation of 1-(piperidin-1-
yl)butane-1,3-dione with aromatic aldehyde and thiourea in ethanol catalyzed by p-toluenesulfonic acid at room temperature
under ultrasound irradiation. The advantages of this methodology are convenient operation, mild conditions, short reaction
times and high yields.
Keywords: Catalysis, condensation, one-pot synthesis, piperidinylamide, 2-thioxo-dihydropyrimidine, ultrasound irradiation.
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