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Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Green Synthesis and Antioxidant Activity of Novel γ-Cyano-α- hydroxyphosphonate Derivatives

Author(s): Iyadh Aouani, Karima Lahbib and Soufiane Touil

Volume 11, Issue 2, 2015

Page: [206 - 213] Pages: 8

DOI: 10.2174/1573406410666140706154046

Price: $65

Abstract

Herein we report an efficient, simple and green synthesis of novel types of α-hydroxyphosphonates bearing a nitrile group, from the reaction of γ-ketonitriles with dialkyl phosphites in the presence of magnesium oxide as solid support, under solvent-free conditions. All the title compounds were screened for their antioxidant activity by 1,1-diphenyl-2- picrylhydrazyl (DPPH), hydroxyl radical, reducing power and ferrous ion chelating (FIC) methods and they showed significant antioxidant activity.

Keywords: α-Hydroxyphosphonates, γ-cyano-α-hydroxyphosphonates, γ-ketonitriles, green synthesis, antioxidant activity.

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