Medicinal Chemistry

Atta-ur-Rahman  
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: mc@benthamscience.org

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Green Synthesis and Antioxidant Activity of Novel γ-Cyano-α- hydroxyphosphonate Derivatives

Author(s): Iyadh Aouani, Karima Lahbib, Soufiane Touil.

Graphical Abstract:


Abstract:

Herein we report an efficient, simple and green synthesis of novel types of α-hydroxyphosphonates bearing a nitrile group, from the reaction of γ-ketonitriles with dialkyl phosphites in the presence of magnesium oxide as solid support, under solvent-free conditions. All the title compounds were screened for their antioxidant activity by 1,1-diphenyl-2- picrylhydrazyl (DPPH), hydroxyl radical, reducing power and ferrous ion chelating (FIC) methods and they showed significant antioxidant activity.

Keywords: α-Hydroxyphosphonates, γ-cyano-α-hydroxyphosphonates, γ-ketonitriles, green synthesis, antioxidant activity.

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2015
Page: [206 - 213]
Pages: 8
DOI: 10.2174/1573406410666140706154046
Price: $58