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Current Medicinal Chemistry
ISSN (Print): 0929-8673
ISSN (Online): 1875-533X
Epub Full Text Article
DOI: 10.2174/0929867321666140706143925      Price:  $95









Nutritional Iron Deficiency: the Role of Oral Iron Supplementation

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Author(s): Joanna I. Lachowicz, Valeria M. Nurchi, Daniela Fanni, Clara Gerosa, Massimiliano Peana and Maria A. Zoroddu
Abstract:
Nutritional iron deficiency represents a relevant health problem mainly in developing countries. Children and pregnant women represent the main target of this disease, and the low amount of bio-available iron mostly depends on plant-based diets. Iron deficiency may have serious consequences, with severe impairment of the immune function leading to infectious diseases. The brain development in embryos and fetuses during gestation can be greatly affected by iron deficiency of the mother with heavy outcomes on the cognition status of children. A better understanding of molecular pathways involved in iron absorption and metabolism should be considered as the basis for new strategies for developing a molecular therapy for iron deficiency. Different therapeutic strategies are here summarized, and iron fortification appears as the best tool
Keywords:
Iron absorption, iron deficiency, iron fortified food, iron metabolism, iron supplement
Affiliation:
Dipartimento di Scienze Chimiche e Geologiche, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato, Italy