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Current Angiogenesis
ISSN (Print): 2211-5528
ISSN (Online): 2211-5536
VOLUME: 3
ISSUE: 2
DOI: 10.2174/2211552802666140704164740      Price:  $58









Anti-Angiogenesis in the Treatment of Genito-Urinary Cancers: Last Updates

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Author(s): Fadi El Karak, Hampig Raphael Kourie, Ralph Chebib, Samer Tabchi, Alain Daher, Joseph Kattan and Marwan Ghosn
Pages 88-96 (9)
Abstract:
Angiogenesis is an essential mechanism for tumor development and proliferation. In the last decade, inhibition of this mechanism has shown mostly encouraging results in different types of cancers. Urogenital cancers (Prostate, Bladder, Testis and Kidney) represent approximately 25% of all diagnosed cancers in both sexes and much effort has been made in order to incorporate anti-angiogenic agents in the treatment of these cancers.

Inhibition of angiogenesis is the cornerstone of therapy in Renal Cell Carcinoma and has shown somewhat promising results in prostate cancer. However, studies in both Urothelial carcinoma and Germ Cell Tumors remain mostly disappointing.

In this paper, we report the landmark trials evaluating anti-angiogenic drugs in uro-genital cancers.

Graphical Abstract:
Keywords:
Anti-angiogenic drugs, bladder, prostate, testis, kidney, tumor angiogenesis, updates.
Affiliation:
Hematology-Oncology Department, Saint Joseph University, Faculty of Medicine, Beirut, Lebanon.