Login

Journal Image
Current Organocatalysis
ISSN (Print): 2213-3372
ISSN (Online): 2213-3380
VOLUME: 1
ISSUE: 2
DOI: 10.2174/2213337201666140702184623









Pyrrolidine Catalyzed Direct Synthesis of 3,5-Diarylcyclohexenones from Acetone and Chalcones

img
Author(s): Sandip J. Wagh, Raghunath Chowdhury and Sunil K. Ghosh
Pages 71-78 (8)
Abstract:
The organo-catalyzed reaction of chalcones with acetone has been described. Pyrrolidine has been found to catalyse the cascade Michael-aldol-dehydration of chalcones and acetone to produce 3,5-diaryl cyclohexenones under mild conditions with good yields. The organocatalytic methodology tolerated a range of substituents on both the aromatic rings of chalcones. The cyclohexenones produced are known to be the precursors for 3,5-diarylphenols, 3,5-diarylanilines and complex heterocycles.
Graphical Abstract:
Keywords:
Atom economic, cascade reaction, chalcones, 3, 5-diarylcyclohexenone, Michael-aldol-dehydration, one-pot synthesis, organocatalysis.
Affiliation:
Bio-Organic Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.