Current Molecular Pharmacology

Michael Kahn
University of Southern California
1450 Biggy Street
Los Angeles, NRT 4501, CA 90033
USA

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Anti-cancer Drug Discovery: Update and Comparisons in Yeast, Drosophila, and Zebrafish

Author(s): Guangxun Gao, Liang Chen, Chuanshu Huang.

Abstract:

Discovery of novel cancer chemotherapeutics focuses on screening and identifying compounds that can target ‘cancer-specific’ biological processes while causing minimal toxicity to non-tumor cells. Alternatively, model organisms with highly conserved cancer-related cellular processes relative to human cells may offer new opportunities for anticancer drug discovery when combined with chemical screening. Some organisms used for chemotherapeutic discovery include yeast, Drosophila, and zebrafish which are similar in important ways relevant to cancer study but offer distinct advantages as well. Here, we describe these model attributes and the rationale for using them in cancer drug screening research.

Keywords: Anti-cancer drug discovery, Drosophila, HTS, model organism, yeast, zebrafish.

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2014
Page: [44 - 51]
Pages: 8
DOI: 10.2174/1874467207666140702113629