Anti-cancer Drug Discovery: Update and Comparisons in Yeast, Drosophila, and Zebrafish
Discovery of novel cancer chemotherapeutics focuses on screening and identifying compounds that can target
‘cancer-specific’ biological processes while causing minimal toxicity to non-tumor cells. Alternatively, model organisms
with highly conserved cancer-related cellular processes relative to human cells may offer new opportunities for anticancer
drug discovery when combined with chemical screening. Some organisms used for chemotherapeutic discovery include
yeast, Drosophila, and zebrafish which are similar in important ways relevant to cancer study but offer distinct advantages
as well. Here, we describe these model attributes and the rationale for using them in cancer drug screening research.
Keywords: Anti-cancer drug discovery, Drosophila, HTS, model organism, yeast, zebrafish.
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