The development of simultaneous decompensation in cardiac and renal function is a common phenomenon in
patients with congestive heart failure. Termed the cardiorenal syndrome (CRS), this joint deterioration in cardiac output
and renal filtration is the result of a complex interplay of hemodynamic and neurohormonal factors. Recently, endothelial
dysfunction, inflammation and uremia have been recognized as contributors to the crosstalk responsible for the
development of CRS. Management strategies for the treatment of CRS involve correction of hemodynamic derangements
and regulation of neurohormonal pathways. Future therapies may target more newly recognized components of CRS
Keywords: Cardiorenal syndrome, heart failure, kidney injury, renal failure, venous congestion, volume overload.
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