Synthesis, Characterisation of β-indolylketones and the Effect of Lipophilicity on the Antimicrobial Activity
Y.L.N. Murthy, Praveen Choppara, Y.V. Prasad and T.J.U. Ranjan
Affiliation: Department of Organic Chemistry, Foods, Drugs & Water, Andhra University, Visakhapatnam, 530 003, India.
Herein, we report cellulose sulfuric acid (CSA) as a heterogeneous, eco-friendly, reusable catalyst for the synthesis
of β -indolylketones via conjugate Micheal addition reactions of indoles, to chalcones in acetonitrile at 80 °C for
1.5–4 h. The structures of the synthesized compounds were evaluated by spectral data. All the synthesized compounds
were screened for their antimicrobial activity against bacterial (S. aureus, K. pneumonia and S. marcescens) and fungal
(C. albicans and A. niger) strains. The aim of this study was to determine the relationship between lipophilicity
and antimicrobial activity of β-indolylketones.
Keywords: β-indolylketones, cellulose sulfuric acid, chalcones, indoles, in vitro antimicrobial activity, lipophilicity, michael
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