Current Pharmaceutical Analysis

Anastasios Economou
Department of Chemistry
Laboratory of Analytical Chemistry
University of Athens
Athens
Greece
Email: cpa@benthamscience.org

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Synthesis, Characterisation of β-indolylketones and the Effect of Lipophilicity on the Antimicrobial Activity

Author(s): Y.L.N. Murthy, Praveen Choppara, Y.V. Prasad and T.J.U. Ranjan

Affiliation: Department of Organic Chemistry, Foods, Drugs & Water, Andhra University, Visakhapatnam, 530 003, India.

Keywords: β-indolylketones, cellulose sulfuric acid, chalcones, indoles, in vitro antimicrobial activity, lipophilicity, michael addition.

Graphical Abstract:


Abstract:

Herein, we report cellulose sulfuric acid (CSA) as a heterogeneous, eco-friendly, reusable catalyst for the synthesis of β -indolylketones via conjugate Micheal addition reactions of indoles, to chalcones in acetonitrile at 80 °C for 1.5–4 h. The structures of the synthesized compounds were evaluated by spectral data. All the synthesized compounds were screened for their antimicrobial activity against bacterial (S. aureus, K. pneumonia and S. marcescens) and fungal (C. albicans and A. niger) strains. The aim of this study was to determine the relationship between lipophilicity and antimicrobial activity of β-indolylketones.

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Article Details

VOLUME: 10
ISSUE: 4
Page: [284 - 292]
Pages: 9
DOI: 10.2174/1573412910666140630165745